plastic injection protects mouse hearts after attack

by:INDUSTRIAL-MAN     2019-08-29
This discovery is a happy accident.
It turns out that the injection of miniature labels made of plastic
Like a polymer, it can help limit tissue damage after a heart attack in mice.
It is hoped that one day it will help to treat this and other diseases of human beings.
Looking for a therapy to shut down inflammatory mongoing-an immune cell that can damage the body after a heart attack and other diseases-is already long and elusive, stephen Miller of Northwestern University in Illinois said.
He and his team have found a way to mark these single-core cells in mice using particles made of biodegradable polymer pla.
This prompts the transfer of the single-core cells from the inflammatory site to the spleen, where they are destroyed.
Other immune cells seem to be intact.
An existing use of particles is laboratory imaging, labeling, and tracking of cells, and the width of the particles is only 1/200 of the hair.
Daniel gates used this method to study how inflammatory single-core cells spread from blood to the brain of West Nile virus mice, where they can damage tissues.
The wrong thing is that a batch of particles carry negative electricity.
Instead of seeing as expected that most of the mice he infected died of brain inflammation, Getts found that the single-core cells had been combined with his charged particles and entered the spleen.
\"We found this to be a complete accident,\" Getts said . \".
He found that 60 of the infected mice survived. The negatively-
Charged particles bind to a receptor protein on the surface of the inflammatory single cell, called \"MARCO \".
\"This protein is usually detected and adhered to negatively charged areas on pathogens, dead cells, and other debris in the blood.
The researchers suspect that the combination of this particular receptor will signal to the single-core cells into the spleen, where the goods and cells are destroyed.
Getts says it is a natural move to try to mark single-core cells in this way in their disease of damaging tissues.
Controlling inflammation after a heart attack is the top priority.
In the first few days after the attack, the single-core cells can target oxygen
The heart muscles are deprived and further damaged.
Mice injected with microparticles 12 hours after the attack had heart disease in half the size of untreated mice.
The heart of the treated mouse also beats better.
This particle helps to reduce spinal cord inflammation in mice with multiple hardening diseases similar to humans and to reduce their paralysis.
Patients with irritable bowel syndrome also showed reduced inflammation of the intestinal mucosa.
Patients with kidney injury have signs of better organ function, suggesting that these labels may be effective after organ transplant.
Miller said the team hopes to start a human clinical trial of the treatment for heart attacks this year.
\"This approach is innovative,\" said Nick janucakis, a pathologist at the University of Pittsburgh Medical Center in Pennsylvania.
But he added that it would be helpful to have a better understanding of the events after the MARCO binding.
Magazine reference and colon;
Scientific translational medicine, classification number and colon cancer. 10.
1126/scitranslmed.
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